Assay Detail
Binding
CHEMBL987066
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Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 (CHEMBL2096661) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.46 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL488318 | — | — | 1 | 9.46 |
| CHEMBL472841 | — | — | 1 | 9.30 |
| CHEMBL520731 | — | — | 1 | 9.30 |
| CHEMBL485857 | — | — | 1 | 9.05 |
| CHEMBL444773 | — | — | 1 | 9.03 |
| CHEMBL521080 | — | — | 1 | 8.85 |
| CHEMBL491402 | — | — | 1 | 8.85 |
| CHEMBL450871 | — | — | 1 | 8.85 |
| CHEMBL478464 | — | — | 1 | 8.77 |
| CHEMBL515393 | — | — | 1 | 8.62 |
| CHEMBL500859 | — | — | 1 | 8.49 |
| CHEMBL479061 | — | — | 1 | 8.36 |
| CHEMBL489362 | — | — | 1 | 8.27 |
| CHEMBL487702 | — | — | 1 | 8.22 |
| CHEMBL486060 | — | — | 1 | 8.15 |
| CHEMBL477593 | — | — | 1 | 7.72 |
| CHEMBL475914 | — | — | 1 | 7.64 |
| CHEMBL478216 | — | — | 1 | 7.55 |
| CHEMBL509676 | — | — | 1 | 7.35 |
| CHEMBL515964 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL488318 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL472841 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL520731 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL485857 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL444773 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL521080 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL491402 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL450871 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL478464 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL515393 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL500859 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL479061 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL489362 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL487702 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL486060 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL477593 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL475914 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL478216 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL509676 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL515964 | — | IC50 | = | 45.0 | nM | 7.35 |