Assay Detail
Functional
CHEMBL987659
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Cytotoxicity against human HL60 cells after 48 hrs by trypan blue exclusion method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
(Hydroxymethyl)acylfulvene: an illudin derivative with superior antitumor properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.49 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | 3.0 | 1 | 7.14 |
| CHEMBL195491 | DEHYDROILLUDIN M | — | 1 | 6.53 |
| CHEMBL517570 | — | — | 1 | 6.42 |
| CHEMBL121987 | ACYLFULVENE | — | 1 | 6.38 |
| CHEMBL445524 | — | — | 1 | 5.98 |
| CHEMBL459698 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL195491 | DEHYDROILLUDIN M | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL517570 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL121987 | ACYLFULVENE | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL445524 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL459698 | — | IC50 | - | — | - |