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Assay Detail

CHEMBL988018

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine brain mitochondrial MAO-B by fluorometric assay
ChEMBL ↗
49
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2756) ↗
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
La Regina G, Silvestri R, Gatti V, Lavecchia A, Novellino E, Befani O, Turini P, Agostinelli E.
Bioorg Med Chem (2008) 16 : 9729 -9740
PubMed 18951803 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 49 6.28 8.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL459336 — — 2 8.82
CHEMBL457235 — — 2 7.82
CHEMBL457031 — — 2 7.80
CHEMBL374335 — — 1 7.70
CHEMBL462097 — — 1 7.70
CHEMBL464798 — — 1 7.68
CHEMBL450824 — — 1 7.60
CHEMBL455989 — — 1 7.52
CHEMBL503807 — — 1 7.43
CHEMBL464597 — — 1 7.03
CHEMBL457422 — — 1 7.00
CHEMBL460608 — — 1 7.00
CHEMBL464799 — — 1 6.92
CHEMBL460610 — — 1 6.72
CHEMBL454487 — — 1 6.64
CHEMBL447043 — — 1 6.50
CHEMBL509973 — — 1 6.30
CHEMBL462054 — — 1 6.16
CHEMBL460609 — — 1 6.10
CHEMBL460829 — — 1 6.03
CHEMBL444747 — — 1 6.02
CHEMBL972 SELEGILINE 4.0 1 6.01
CHEMBL461245 — — 1 6.00
CHEMBL456107 — — 1 5.80
CHEMBL457212 — — 1 5.28
CHEMBL510210 — — 1 5.23
CHEMBL461244 — — 1 5.08
CHEMBL462096 — — 1 5.01
CHEMBL459543 — — 1 5.00
CHEMBL459962 — — 1 4.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL459336 — Ki = 1.5 nM 8.82
CHEMBL459336 — Ki = 1.585 nM 8.80
CHEMBL457235 — Ki = 15.0 nM 7.82
CHEMBL457031 — Ki = 15.85 nM 7.80
CHEMBL457235 — Ki = 15.85 nM 7.80
CHEMBL457031 — Ki = 16.0 nM 7.80
CHEMBL374335 — Ki = 20.0 nM 7.70
CHEMBL462097 — Ki = 20.0 nM 7.70
CHEMBL464798 — Ki = 21.0 nM 7.68
CHEMBL450824 — Ki = 25.0 nM 7.60
CHEMBL455989 — Ki = 30.0 nM 7.52
CHEMBL503807 — Ki = 37.0 nM 7.43
CHEMBL464597 — Ki = 94.0 nM 7.03
CHEMBL457422 — Ki = 100.0 nM 7.00
CHEMBL460608 — Ki = 100.0 nM 7.00
CHEMBL464799 — Ki = 120.0 nM 6.92
CHEMBL460610 — Ki = 190.0 nM 6.72
CHEMBL454487 — Ki = 230.0 nM 6.64
CHEMBL447043 — Ki = 320.0 nM 6.50
CHEMBL509973 — Ki = 500.0 nM 6.30
CHEMBL462054 — Ki = 700.0 nM 6.16
CHEMBL460609 — Ki = 800.0 nM 6.10
CHEMBL460829 — Ki = 930.0 nM 6.03
CHEMBL444747 — Ki = 960.0 nM 6.02
CHEMBL972 SELEGILINE Ki = 970.0 nM 6.01
CHEMBL461245 — Ki = 1000.0 nM 6.00
CHEMBL456107 — Ki = 1600.0 nM 5.80
CHEMBL457212 — Ki = 5300.0 nM 5.28
CHEMBL510210 — Ki = 5900.0 nM 5.23
CHEMBL461244 — Ki = 8300.0 nM 5.08
CHEMBL462096 — Ki = 9700.0 nM 5.01
CHEMBL459543 — Ki = 10000.0 nM 5.00
CHEMBL459962 — Ki = 11000.0 nM 4.96
CHEMBL457030 — Ki = 23000.0 nM 4.64
CHEMBL460828 — Ki = 25000.0 nM 4.60
CHEMBL8706 CLORGILINE Ki = 58000.0 nM 4.24
CHEMBL460599 — Ki = 63095.73 nM 4.20
CHEMBL460599 — Ki = 63000.0 nM 4.20
CHEMBL449889 — Ki = 75000.0 nM 4.12
CHEMBL512732 — Ki = 92000.0 nM 4.04
CHEMBL459544 — Ki > 100000.0 nM -
CHEMBL464333 — Ki > 100000.0 nM -
CHEMBL507759 — Ki > 100000.0 nM -
CHEMBL45511 — Ki > 100000.0 nM -
CHEMBL223300 — Ki = 300000.0 nM -
CHEMBL446960 — Ki > 100000.0 nM -
CHEMBL86304 MOCLOBEMIDE Ki > 100000.0 nM -
CHEMBL455981 — Ki > 100000.0 nM -
CHEMBL448946 — Ki > 100000.0 nM -