Assay Detail
Functional
CHEMBL988435
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Vasodilatory activity in Sprague-Dawley rat endothelium-intact thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.93 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486598 | EVODIAMINE | — | 1 | 6.03 |
| CHEMBL85139 | RUTAECARPINE | — | 1 | 5.98 |
| CHEMBL81923 | DEHYDROEVODIAMINE | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486598 | EVODIAMINE | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL85139 | RUTAECARPINE | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL81923 | DEHYDROEVODIAMINE | EC50 | = | 1640.0 | nM | 5.79 |