Assay Detail
Binding
CHEMBL988698
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Displacement of [125I]IMPY from beta-amyloid plaques in Alzheimer's disease patient brain homogenate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 18F-labelled 2-(4'-fluorophenyl)-1,3-benzothiazole and evaluation as amyloid imaging agent in comparison with [11C]PIB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.30 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207456 | PITTSBURGH COMPOUND B | 2.0 | 1 | 8.55 |
| CHEMBL477841 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207456 | PITTSBURGH COMPOUND B | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL477841 | — | Ki | = | 9.0 | nM | 8.05 |