Assay Detail
Binding
CHEMBL989216
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Binding affinity at human progesterone receptor
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.46 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507701 | — | — | 1 | 8.92 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 8.85 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.47 |
| CHEMBL453579 | — | — | 3 | 8.43 |
| CHEMBL510305 | — | — | 1 | 8.32 |
| CHEMBL510373 | — | — | 1 | 7.85 |
| CHEMBL507532 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507701 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL103 | PROGESTERONE | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL453579 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL453579 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL510305 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL510373 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL507532 | — | Ki | - | — | - | |
| CHEMBL453579 | — | Ki | > | 1000.0 | nM | - |