Assay Detail
Binding
CHEMBL989262
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Inhibition of pig erythrocyte mu-calpain by fluorometric assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural basis for the potent calpain inhibitory activity of peptidyl alpha-ketoacids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.81 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480969 | — | — | 1 | 8.10 |
| CHEMBL423112 | — | — | 1 | 8.00 |
| CHEMBL518149 | — | — | 1 | 7.39 |
| CHEMBL480782 | — | — | 1 | 7.30 |
| CHEMBL482105 | — | — | 1 | 7.20 |
| CHEMBL482093 | — | — | 1 | 6.97 |
| CHEMBL482077 | — | — | 1 | 6.35 |
| CHEMBL482092 | — | — | 1 | 6.03 |
| CHEMBL520418 | — | — | 1 | 5.98 |
| CHEMBL482267 | — | — | 1 | 5.92 |
| CHEMBL479976 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480969 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL423112 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL518149 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL480782 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL482105 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL482093 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL482077 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL482092 | — | Ki | = | 944.0 | nM | 6.03 |
| CHEMBL520418 | — | Ki | = | 1048.0 | nM | 5.98 |
| CHEMBL482267 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL479976 | — | Ki | = | 2150.0 | nM | 5.67 |