Assay Detail
Functional
CHEMBL989634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phenylephrine-induced contraction of smooth muscles in New Zealand white rabbit endothelium-intact aorta
42
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluations of sildenafil analogues for treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 7.16 | 7.46 |
| Emax | 21 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510226 | — | — | 2 | 7.46 |
| CHEMBL512979 | — | — | 2 | 7.40 |
| CHEMBL513873 | — | — | 2 | 7.32 |
| CHEMBL492795 | — | — | 2 | 7.28 |
| CHEMBL467592 | — | — | 2 | 7.28 |
| CHEMBL467593 | — | — | 2 | 7.28 |
| CHEMBL192 | SILDENAFIL | 4.0 | 2 | 7.25 |
| CHEMBL449906 | — | — | 2 | 7.22 |
| CHEMBL507524 | — | — | 2 | 7.21 |
| CHEMBL494817 | — | — | 2 | 7.21 |
| CHEMBL468571 | — | — | 2 | 7.18 |
| CHEMBL498866 | — | — | 2 | 7.18 |
| CHEMBL511065 | — | — | 2 | 7.18 |
| CHEMBL468760 | — | — | 2 | 7.16 |
| CHEMBL464341 | — | — | 2 | 7.08 |
| CHEMBL510554 | — | — | 2 | 7.07 |
| CHEMBL506893 | — | — | 2 | 7.04 |
| CHEMBL464131 | — | — | 2 | 7.02 |
| CHEMBL505194 | — | — | 2 | 6.93 |
| CHEMBL504620 | — | — | 2 | 6.81 |
| CHEMBL468572 | — | — | 2 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510226 | — | EC50 | = | 34.67 | nM | 7.46 |
| CHEMBL512979 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL513873 | — | EC50 | = | 47.86 | nM | 7.32 |
| CHEMBL467592 | — | EC50 | = | 52.48 | nM | 7.28 |
| CHEMBL467593 | — | EC50 | = | 52.48 | nM | 7.28 |
| CHEMBL492795 | — | EC50 | = | 52.48 | nM | 7.28 |
| CHEMBL192 | SILDENAFIL | EC50 | = | 56.23 | nM | 7.25 |
| CHEMBL449906 | — | EC50 | = | 60.26 | nM | 7.22 |
| CHEMBL507524 | — | EC50 | = | 61.66 | nM | 7.21 |
| CHEMBL494817 | — | EC50 | = | 61.66 | nM | 7.21 |
| CHEMBL511065 | — | EC50 | = | 66.07 | nM | 7.18 |
| CHEMBL468571 | — | EC50 | = | 66.07 | nM | 7.18 |
| CHEMBL498866 | — | EC50 | = | 66.07 | nM | 7.18 |
| CHEMBL468760 | — | EC50 | = | 69.18 | nM | 7.16 |
| CHEMBL464341 | — | EC50 | = | 83.18 | nM | 7.08 |
| CHEMBL510554 | — | EC50 | = | 85.11 | nM | 7.07 |
| CHEMBL506893 | — | EC50 | = | 91.2 | nM | 7.04 |
| CHEMBL464131 | — | EC50 | = | 95.5 | nM | 7.02 |
| CHEMBL505194 | — | EC50 | = | 117.49 | nM | 6.93 |
| CHEMBL504620 | — | EC50 | = | 154.88 | nM | 6.81 |
| CHEMBL468572 | — | EC50 | = | 169.82 | nM | 6.77 |
| CHEMBL468571 | — | Emax | = | 59.0 | % | - |
| CHEMBL510554 | — | Emax | = | 69.0 | % | - |
| CHEMBL505194 | — | Emax | = | 75.0 | % | - |
| CHEMBL507524 | — | Emax | = | 73.0 | % | - |
| CHEMBL492795 | — | Emax | = | 70.0 | % | - |
| CHEMBL494817 | — | Emax | = | 82.0 | % | - |
| CHEMBL192 | SILDENAFIL | Emax | = | 76.0 | % | - |
| CHEMBL506893 | — | Emax | = | 87.0 | % | - |
| CHEMBL510226 | — | Emax | = | 93.0 | % | - |
| CHEMBL513873 | — | Emax | = | 91.0 | % | - |
| CHEMBL504620 | — | Emax | = | 66.0 | % | - |
| CHEMBL498866 | — | Emax | = | 77.0 | % | - |
| CHEMBL464341 | — | Emax | = | 74.0 | % | - |
| CHEMBL511065 | — | Emax | = | 72.0 | % | - |
| CHEMBL464131 | — | Emax | = | 66.0 | % | - |
| CHEMBL468572 | — | Emax | = | 69.0 | % | - |
| CHEMBL512979 | — | Emax | = | 91.0 | % | - |
| CHEMBL468760 | — | Emax | = | 63.0 | % | - |
| CHEMBL449906 | — | Emax | = | 86.0 | % | - |
| CHEMBL467592 | — | Emax | = | 90.0 | % | - |
| CHEMBL467593 | — | Emax | = | 89.0 | % | - |