Assay Detail
Functional
CHEMBL989635
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phenylephrine-induced contraction of smooth muscles in New Zealand white rabbit denuded aorta
42
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluations of sildenafil analogues for treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 6.65 | 7.01 |
| Emax | 21 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494817 | — | — | 2 | 7.01 |
| CHEMBL505194 | — | — | 2 | 6.81 |
| CHEMBL449906 | — | — | 2 | 6.78 |
| CHEMBL512979 | — | — | 2 | 6.76 |
| CHEMBL492795 | — | — | 2 | 6.75 |
| CHEMBL468571 | — | — | 2 | 6.74 |
| CHEMBL507524 | — | — | 2 | 6.73 |
| CHEMBL467593 | — | — | 2 | 6.71 |
| CHEMBL511065 | — | — | 2 | 6.69 |
| CHEMBL510226 | — | — | 2 | 6.68 |
| CHEMBL467592 | — | — | 2 | 6.68 |
| CHEMBL513873 | — | — | 2 | 6.64 |
| CHEMBL464341 | — | — | 2 | 6.61 |
| CHEMBL192 | SILDENAFIL | 4.0 | 2 | 6.57 |
| CHEMBL468760 | — | — | 2 | 6.54 |
| CHEMBL506893 | — | — | 2 | 6.54 |
| CHEMBL464131 | — | — | 2 | 6.49 |
| CHEMBL468572 | — | — | 2 | 6.48 |
| CHEMBL498866 | — | — | 2 | 6.48 |
| CHEMBL510554 | — | — | 2 | 6.47 |
| CHEMBL504620 | — | — | 2 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494817 | — | EC50 | = | 97.72 | nM | 7.01 |
| CHEMBL505194 | — | EC50 | = | 154.88 | nM | 6.81 |
| CHEMBL449906 | — | EC50 | = | 165.96 | nM | 6.78 |
| CHEMBL512979 | — | EC50 | = | 173.78 | nM | 6.76 |
| CHEMBL492795 | — | EC50 | = | 177.83 | nM | 6.75 |
| CHEMBL468571 | — | EC50 | = | 181.97 | nM | 6.74 |
| CHEMBL507524 | — | EC50 | = | 186.21 | nM | 6.73 |
| CHEMBL467593 | — | EC50 | = | 194.98 | nM | 6.71 |
| CHEMBL511065 | — | EC50 | = | 204.17 | nM | 6.69 |
| CHEMBL510226 | — | EC50 | = | 208.93 | nM | 6.68 |
| CHEMBL467592 | — | EC50 | = | 208.93 | nM | 6.68 |
| CHEMBL513873 | — | EC50 | = | 229.09 | nM | 6.64 |
| CHEMBL464341 | — | EC50 | = | 245.47 | nM | 6.61 |
| CHEMBL192 | SILDENAFIL | EC50 | = | 269.15 | nM | 6.57 |
| CHEMBL506893 | — | EC50 | = | 288.4 | nM | 6.54 |
| CHEMBL468760 | — | EC50 | = | 288.4 | nM | 6.54 |
| CHEMBL464131 | — | EC50 | = | 323.59 | nM | 6.49 |
| CHEMBL468572 | — | EC50 | = | 331.13 | nM | 6.48 |
| CHEMBL498866 | — | EC50 | = | 331.13 | nM | 6.48 |
| CHEMBL510554 | — | EC50 | = | 338.84 | nM | 6.47 |
| CHEMBL504620 | — | EC50 | = | 380.19 | nM | 6.42 |
| CHEMBL468571 | — | Emax | = | 41.0 | % | - |
| CHEMBL510554 | — | Emax | = | 51.0 | % | - |
| CHEMBL505194 | — | Emax | = | 68.0 | % | - |
| CHEMBL507524 | — | Emax | = | 69.0 | % | - |
| CHEMBL492795 | — | Emax | = | 66.0 | % | - |
| CHEMBL494817 | — | Emax | = | 82.0 | % | - |
| CHEMBL192 | SILDENAFIL | Emax | = | 56.0 | % | - |
| CHEMBL506893 | — | Emax | = | 88.0 | % | - |
| CHEMBL510226 | — | Emax | = | 72.0 | % | - |
| CHEMBL513873 | — | Emax | = | 60.0 | % | - |
| CHEMBL504620 | — | Emax | = | 42.0 | % | - |
| CHEMBL498866 | — | Emax | = | 46.0 | % | - |
| CHEMBL464341 | — | Emax | = | 52.0 | % | - |
| CHEMBL511065 | — | Emax | = | 61.0 | % | - |
| CHEMBL464131 | — | Emax | = | 47.0 | % | - |
| CHEMBL468572 | — | Emax | = | 49.0 | % | - |
| CHEMBL512979 | — | Emax | = | 73.0 | % | - |
| CHEMBL468760 | — | Emax | = | 40.0 | % | - |
| CHEMBL449906 | — | Emax | = | 70.0 | % | - |
| CHEMBL467592 | — | Emax | = | 75.0 | % | - |
| CHEMBL467593 | — | Emax | = | 67.0 | % | - |