Assay Detail
Functional
CHEMBL989663
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Antiproliferative activity against bovine microvascular endothelial cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Cell Type | Endothelial cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of fluorinated combretastatin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.56 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466554 | — | — | 1 | 7.64 |
| CHEMBL467765 | — | — | 1 | 7.31 |
| CHEMBL466552 | — | — | 1 | 7.06 |
| CHEMBL468413 | — | — | 1 | 6.77 |
| CHEMBL512245 | — | — | 1 | 6.41 |
| CHEMBL467598 | — | — | 1 | 5.77 |
| CHEMBL468194 | — | — | 1 | 5.70 |
| CHEMBL466357 | — | — | 1 | 5.68 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.58 |
| CHEMBL330407 | — | — | 1 | 5.51 |
| CHEMBL468014 | — | — | 1 | 5.44 |
| CHEMBL468580 | — | — | 1 | 5.34 |
| CHEMBL468629 | — | — | 1 | 5.33 |
| CHEMBL467774 | — | — | 1 | 4.89 |
| CHEMBL468213 | — | — | 1 | 4.64 |
| CHEMBL468630 | — | — | 1 | 4.58 |
| CHEMBL512995 | — | — | 1 | 4.57 |
| CHEMBL468647 | — | — | 1 | 4.42 |
| CHEMBL466553 | — | — | 1 | 4.42 |
| CHEMBL466356 | — | — | 1 | 4.07 |
| CHEMBL513860 | — | — | 1 | - |
| CHEMBL467780 | — | — | 1 | - |
| CHEMBL512641 | — | — | 1 | - |
| CHEMBL192224 | — | — | 1 | - |
| CHEMBL468646 | — | — | 1 | - |
| CHEMBL468648 | — | — | 1 | - |
| CHEMBL468998 | — | — | 1 | - |
| CHEMBL466148 | — | — | 1 | - |
| CHEMBL468193 | — | — | 1 | - |
| CHEMBL466358 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466554 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL467765 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL466552 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL468413 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL512245 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL467598 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL468194 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL466357 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL330407 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL468014 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL468580 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL468629 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL467774 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL468213 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL468630 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL512995 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL468647 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL466553 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL466356 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL513860 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL467780 | — | IC50 | = | 749000.0 | nM | - |
| CHEMBL512641 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL192224 | — | IC50 | = | 135000.0 | nM | - |
| CHEMBL468646 | — | IC50 | = | 2300000.0 | nM | - |
| CHEMBL468648 | — | IC50 | = | 2800000.0 | nM | - |
| CHEMBL468998 | — | IC50 | = | 329000.0 | nM | - |
| CHEMBL466148 | — | IC50 | > | 3000000.0 | nM | - |
| CHEMBL468193 | — | IC50 | = | 204000.0 | nM | - |
| CHEMBL466358 | — | IC50 | = | 111000.0 | nM | - |
| CHEMBL467957 | — | IC50 | = | 610000.0 | nM | - |