Assay Detail
Binding
CHEMBL989749
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Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.70 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515342 | — | — | 1 | 8.00 |
| CHEMBL478671 | — | — | 1 | 7.92 |
| CHEMBL515187 | — | — | 1 | 7.75 |
| CHEMBL403550 | — | — | 1 | 7.64 |
| CHEMBL516580 | — | — | 1 | 7.51 |
| CHEMBL27559 | — | — | 1 | 7.35 |
| CHEMBL478043 | — | — | 1 | - |
| CHEMBL255229 | — | — | 1 | - |
| CHEMBL455318 | — | — | 1 | - |
| CHEMBL509451 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515342 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL478671 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL515187 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL403550 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL516580 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL27559 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL478043 | — | Ki | - | — | - | |
| CHEMBL255229 | — | Ki | - | — | - | |
| CHEMBL455318 | — | Ki | - | — | - | |
| CHEMBL509451 | — | Ki | - | — | - |