Assay Detail
ADMET
CHEMBL989843
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Inhibition of human recombinant CYP1A2 expressed in baculovirus-infected insect microsomes
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.74 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL461884 | — | — | 1 | 6.75 |
| CHEMBL460178 | — | — | 1 | 6.36 |
| CHEMBL461458 | — | — | 1 | 6.22 |
| CHEMBL459969 | — | — | 1 | 6.21 |
| CHEMBL511329 | — | — | 1 | 6.19 |
| CHEMBL459970 | — | — | 1 | 6.18 |
| CHEMBL462093 | — | — | 1 | 5.81 |
| CHEMBL448743 | — | — | 1 | 5.81 |
| CHEMBL499007 | — | — | 1 | 5.81 |
| CHEMBL446083 | — | — | 1 | 5.75 |
| CHEMBL62811 | — | — | 1 | 5.71 |
| CHEMBL405845 | FURAFYLLINE | 2.0 | 1 | 5.62 |
| CHEMBL457425 | — | — | 1 | 5.46 |
| CHEMBL457646 | — | — | 1 | 5.28 |
| CHEMBL459071 | — | — | 1 | 5.18 |
| CHEMBL457856 | — | — | 1 | 4.78 |
| CHEMBL457640 | — | — | 1 | 4.51 |
| CHEMBL456390 | — | — | 1 | - |
| CHEMBL365735 | — | — | 1 | - |
| CHEMBL362968 | — | — | 1 | - |
| CHEMBL196796 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL461884 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL460178 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL461458 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL459969 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL511329 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL459970 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL462093 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL448743 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL499007 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL446083 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL62811 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL405845 | FURAFYLLINE | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL457425 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL457646 | — | IC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL459071 | — | IC50 | = | 6580.0 | nM | 5.18 |
| CHEMBL457856 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL457640 | — | IC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL456390 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL365735 | — | IC50 | - | — | - | |
| CHEMBL362968 | — | IC50 | - | — | - | |
| CHEMBL196796 | — | IC50 | - | — | - |