Assay Detail
Functional
CHEMBL990247
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against rat A10 cells assessed as loss of cellular microtubule after 18 hrs by indirect immunofluorescence
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | A10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 9.41 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | 2.0 | 1 | 9.60 |
| CHEMBL501233 | SYMPLOSTATIN 1 | — | 1 | 9.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | EC50 | = | 0.25 | nM | 9.60 |
| CHEMBL501233 | SYMPLOSTATIN 1 | EC50 | = | 0.6 | nM | 9.22 |