Assay Detail
Functional
CHEMBL990360
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Antiproliferative activity against human BT474 cells expressing ErbB2 after 72 hrs by CTG assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.73 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475768 | — | — | 1 | 6.38 |
| CHEMBL480349 | — | — | 1 | 6.38 |
| CHEMBL475446 | — | — | 1 | 6.20 |
| CHEMBL475594 | — | — | 1 | 5.73 |
| CHEMBL506414 | GW684626B | — | 1 | 5.49 |
| CHEMBL473427 | — | — | 1 | 5.24 |
| CHEMBL479800 | — | — | 1 | 4.67 |
| CHEMBL514938 | GSK-969786A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475768 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL480349 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL475446 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL475594 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL506414 | GW684626B | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL473427 | — | IC50 | = | 5770.0 | nM | 5.24 |
| CHEMBL479800 | — | IC50 | = | 21250.0 | nM | 4.67 |
| CHEMBL514938 | GSK-969786A | IC50 | > | 30000.0 | nM | - |