Assay Detail
Functional
CHEMBL990363
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Antiproliferative activity against human BT474 cells expressing ErbB2 by MEB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.25 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201179 | LAPATINIB DITOSYLATE | 4.0 | 1 | 7.00 |
| CHEMBL473436 | — | — | 1 | 6.27 |
| CHEMBL474431 | — | — | 1 | 6.22 |
| CHEMBL473428 | — | — | 1 | 6.14 |
| CHEMBL475769 | — | — | 1 | 6.14 |
| CHEMBL475600 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201179 | LAPATINIB DITOSYLATE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL473436 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL474431 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL473428 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL475769 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL475600 | — | IC50 | = | 1980.0 | nM | 5.70 |