Assay Detail
Functional
CHEMBL990601
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Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecule modulators of toll-like receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.99 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3301672 | ERITORAN TETRASODIUM | 3.0 | 1 | 8.82 |
| CHEMBL458612 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3301672 | ERITORAN TETRASODIUM | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL458612 | — | IC50 | = | 7000.0 | nM | 5.16 |