Compound Detail
CHEMBL3301672
ERITORAN TETRASODIUM 🧪 Phase III
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🧪 Phase III
CCCCCC/C=C\CCCCCCCCCC(=O)N[C@H]1[C@H](OC[C@H]2O[C@H](OP(=O)([O-])[O-])[C@H](NC(=O)CC(=O)CCCCCCCCCCC)[C@@H](OCCCCCCCCCC)[C@@H]2O)O[C@H](COC)[C@@H](OP(=O)([O-])[O-])[C@@H]1OCC[C@@H](CCCCCCC)OC.[Na+].[Na+].[Na+].[Na+]
Basic Information
| ChEMBL ID | CHEMBL3301672 |
| Name | ERITORAN TETRASODIUM |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | FEMINZOAAWPBPP-RHMAUSBNSA-J |
| Parent Compound | CHEMBL501259 |
| Active Moiety | CHEMBL501259 |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
7
Known Names
2
Indications
1
Mechanisms
Molecular Properties
1313.7
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Toll-like receptor 4/MD-2 antagonist | ANTAGONIST | Toll-like receptor 4/MD-2 | ✓ | ✓ |
Indications
Sepsis Leukemia
Activity Summary
IC50 2 meas. best 8.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Toll-like receptor 4 CHEMBL5255 | IC50 | 8.82 | 8.82 | 1.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Toll-like receptor 4 | IC50 | = | 1.5 | nM | 8.82 | Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase r... | 18828583 |
| Toll-like receptor 4 | IC50 | = | 1.5 | nM | 8.82 | Antagonist activity at TLR4 in human HL60 cells assessed as inhibition of LPS-in... | 18828583 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18828583 | 10.1021/jm800957k | Toll-like receptor 4 | 2 |
Data from ChEMBL 36 via Core Engine