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Assay Detail

CHEMBL990606

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Binding
Binding affinity to 16S RNA by surface plasmon resonance
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA.
Mei H, Xing L, Cai L, Jin HW, Zhao P, Yang ZJ, Zhang LR, Zhang LH.
Bioorg Med Chem Lett (2008) 18 : 5355 -5358
PubMed 18829307 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 14 4.93 5.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL508308 1 5.10
CHEMBL501935 1 5.05
CHEMBL501226 1 4.96
CHEMBL427409 NEAMINE 1 4.96
CHEMBL448725 1 4.92
CHEMBL503098 1 4.85
CHEMBL504786 1 4.80
CHEMBL502673 1 4.77
CHEMBL500904 1 -
CHEMBL503988 1 -
CHEMBL501185 1 -
CHEMBL507919 1 -
CHEMBL503321 1 -
CHEMBL447145 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL508308 Kd = 8000.0 nM 5.10
CHEMBL501935 Kd = 9000.0 nM 5.05
CHEMBL501226 Kd = 11000.0 nM 4.96
CHEMBL427409 NEAMINE Kd = 11000.0 nM 4.96
CHEMBL448725 Kd = 12000.0 nM 4.92
CHEMBL503098 Kd = 14000.0 nM 4.85
CHEMBL504786 Kd = 16000.0 nM 4.80
CHEMBL502673 Kd = 17000.0 nM 4.77
CHEMBL500904 Kd = 304000.0 nM -
CHEMBL503988 Kd = 180000.0 nM -
CHEMBL501185 Kd = 352000.0 nM -
CHEMBL507919 Kd = 227000.0 nM -
CHEMBL503321 Kd = 316000.0 nM -
CHEMBL447145 Kd = 208000.0 nM -