Assay Detail
Functional
CHEMBL990644
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream trypomastigotes
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 7.43 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442644 | — | — | 1 | 8.70 |
| CHEMBL447285 | — | — | 1 | 8.70 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.52 |
| CHEMBL354342 | — | — | 1 | 8.52 |
| CHEMBL520518 | — | — | 1 | 8.52 |
| CHEMBL449450 | — | — | 1 | 8.52 |
| CHEMBL443628 | — | — | 1 | 8.52 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.40 |
| CHEMBL484548 | — | — | 1 | 8.40 |
| CHEMBL464397 | — | — | 1 | 8.40 |
| CHEMBL520186 | — | — | 1 | 8.30 |
| CHEMBL520013 | — | — | 1 | 8.22 |
| CHEMBL500330 | — | — | 1 | 8.15 |
| CHEMBL485423 | — | — | 1 | 8.10 |
| CHEMBL464601 | — | — | 1 | 8.05 |
| CHEMBL485573 | — | — | 1 | 8.00 |
| CHEMBL485439 | — | — | 1 | 7.96 |
| CHEMBL458546 | — | — | 1 | 7.96 |
| CHEMBL48217 | DAPI | — | 1 | 7.77 |
| CHEMBL518085 | — | — | 1 | 7.77 |
| CHEMBL485224 | — | — | 1 | 7.75 |
| CHEMBL484351 | — | — | 1 | 7.68 |
| CHEMBL485417 | — | — | 1 | 7.68 |
| CHEMBL485225 | — | — | 1 | 7.64 |
| CHEMBL483399 | — | — | 1 | 7.62 |
| CHEMBL484563 | — | — | 1 | 7.57 |
| CHEMBL484195 | — | — | 1 | 7.55 |
| CHEMBL511688 | — | — | 1 | 7.54 |
| CHEMBL485438 | — | — | 1 | 7.31 |
| CHEMBL519519 | — | — | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442644 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL447285 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL354342 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL520518 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL449450 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL443628 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL166 | MELARSOPROL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL484548 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL464397 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL520186 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL520013 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL500330 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL485423 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL464601 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL485573 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL485439 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL458546 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL48217 | DAPI | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL518085 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL485224 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL484351 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL485417 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL485225 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL483399 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL484563 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL484195 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL511688 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL485438 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL519519 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL485235 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL483572 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL458959 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL484194 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL520654 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL484737 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL485410 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL506885 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL520335 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL353802 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL520143 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL520807 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL521501 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL485414 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL451356 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL520485 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL483571 | — | IC50 | = | 473.0 | nM | 6.33 |
| CHEMBL484181 | — | IC50 | = | 534.0 | nM | 6.27 |
| CHEMBL448231 | — | IC50 | = | 606.0 | nM | 6.22 |
| CHEMBL464396 | — | IC50 | = | 929.0 | nM | 6.03 |