Assay Detail
Binding
CHEMBL990676
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Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrate
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.79 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456799 | — | — | 1 | 9.30 |
| CHEMBL456593 | — | — | 1 | 8.64 |
| CHEMBL515506 | — | — | 1 | 8.26 |
| CHEMBL516941 | — | — | 1 | 7.91 |
| CHEMBL518382 | — | — | 1 | 7.90 |
| CHEMBL456592 | — | — | 1 | 7.78 |
| CHEMBL456798 | — | — | 1 | 7.78 |
| CHEMBL461249 | — | — | 1 | 7.77 |
| CHEMBL384023 | — | — | 1 | 7.60 |
| CHEMBL516490 | — | — | 1 | 7.58 |
| CHEMBL439753 | — | — | 1 | 7.38 |
| CHEMBL515661 | — | — | 1 | 7.30 |
| CHEMBL372607 | — | — | 1 | 7.11 |
| CHEMBL461248 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456799 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL456593 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL515506 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL516941 | — | EC50 | = | 12.4 | nM | 7.91 |
| CHEMBL518382 | — | EC50 | = | 12.6 | nM | 7.90 |
| CHEMBL456592 | — | EC50 | = | 16.8 | nM | 7.78 |
| CHEMBL456798 | — | EC50 | = | 16.7 | nM | 7.78 |
| CHEMBL461249 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL384023 | — | EC50 | = | 25.3 | nM | 7.60 |
| CHEMBL516490 | — | EC50 | = | 26.1 | nM | 7.58 |
| CHEMBL439753 | — | EC50 | = | 41.8 | nM | 7.38 |
| CHEMBL515661 | — | EC50 | = | 50.1 | nM | 7.30 |
| CHEMBL372607 | — | EC50 | = | 78.6 | nM | 7.11 |
| CHEMBL461248 | — | EC50 | = | 199.5 | nM | 6.70 |