Assay Detail
Binding
CHEMBL990799
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Inhibition of c-kit
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of amido-benzisoxazoles as potent c-Kit inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.07 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490823 | — | — | 1 | 9.00 |
| CHEMBL488984 | — | — | 1 | 9.00 |
| CHEMBL523816 | — | — | 1 | 8.70 |
| CHEMBL489196 | — | — | 1 | 8.52 |
| CHEMBL491429 | — | — | 1 | 8.52 |
| CHEMBL488985 | — | — | 1 | 8.40 |
| CHEMBL484885 | — | — | 1 | 8.40 |
| CHEMBL519520 | — | — | 1 | 8.30 |
| CHEMBL489579 | — | — | 1 | 8.15 |
| CHEMBL489786 | — | — | 1 | 8.15 |
| CHEMBL490407 | — | — | 1 | 8.10 |
| CHEMBL491628 | — | — | 1 | 7.96 |
| CHEMBL484883 | — | — | 1 | 7.96 |
| CHEMBL490408 | — | — | 1 | 7.96 |
| CHEMBL259247 | — | — | 1 | 7.85 |
| CHEMBL491238 | — | — | 1 | 7.70 |
| CHEMBL521788 | — | — | 1 | 7.55 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 7.24 |
| CHEMBL484884 | — | — | 1 | 7.23 |
| CHEMBL491418 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490823 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL488984 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL523816 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL489196 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL491429 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL488985 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL484885 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL519520 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL489579 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL489786 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL490407 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL491628 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL484883 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL490408 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL259247 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL491238 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL521788 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL941 | IMATINIB | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL484884 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL491418 | — | IC50 | = | 170.0 | nM | 6.77 |