Assay Detail
Binding
CHEMBL990831
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Inhibition of mouse group2E phospholipase A2 fluorimetric assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Group IIE secretory phospholipase A2 (CHEMBL4201) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.05 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514692 | — | — | 1 | 7.92 |
| CHEMBL515637 | — | — | 1 | 7.75 |
| CHEMBL332993 | — | — | 1 | 7.46 |
| CHEMBL446349 | — | — | 1 | 7.32 |
| CHEMBL148674 | VARESPLADIB | 2.0 | 1 | 7.12 |
| CHEMBL148649 | — | — | 1 | 6.85 |
| CHEMBL514841 | — | — | 1 | 6.82 |
| CHEMBL517821 | — | — | 1 | 6.39 |
| CHEMBL514705 | — | — | 1 | 5.82 |
| CHEMBL479251 | — | — | 1 | - |
| CHEMBL504813 | — | — | 1 | - |
| CHEMBL506485 | — | — | 1 | - |
| CHEMBL478820 | — | — | 1 | - |
| CHEMBL478821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514692 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL515637 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL332993 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL446349 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL148674 | VARESPLADIB | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL148649 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL514841 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL517821 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL514705 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL479251 | — | IC50 | > | 1600.0 | nM | - |
| CHEMBL504813 | — | IC50 | > | 1600.0 | nM | - |
| CHEMBL506485 | — | IC50 | > | 1600.0 | nM | - |
| CHEMBL478820 | — | IC50 | > | 1600.0 | nM | - |
| CHEMBL478821 | — | IC50 | > | 230.0 | nM | - |