Assay Detail
Binding
CHEMBL990976
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Inhibition of human recombinant leukotriene A4 hydrolase by enzyme immunoassay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.53 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482254 | — | — | 1 | 8.40 |
| CHEMBL518156 | — | — | 1 | 8.22 |
| CHEMBL479958 | — | — | 1 | 8.15 |
| CHEMBL479383 | — | — | 1 | 8.10 |
| CHEMBL446514 | — | — | 1 | 8.10 |
| CHEMBL481343 | — | — | 1 | 8.05 |
| CHEMBL518155 | — | — | 1 | 8.00 |
| CHEMBL481280 | — | — | 1 | 7.96 |
| CHEMBL481863 | — | — | 1 | 7.96 |
| CHEMBL472138 | — | — | 1 | 7.96 |
| CHEMBL480131 | — | — | 1 | 7.92 |
| CHEMBL480130 | — | — | 1 | 7.92 |
| CHEMBL480137 | — | — | 1 | 7.89 |
| CHEMBL521259 | — | — | 1 | 7.89 |
| CHEMBL482058 | — | — | 1 | 7.89 |
| CHEMBL481351 | — | — | 1 | 7.85 |
| CHEMBL519127 | — | — | 1 | 7.85 |
| CHEMBL480336 | — | — | 1 | 7.80 |
| CHEMBL517533 | — | — | 1 | 7.77 |
| CHEMBL470753 | — | — | 1 | 7.77 |
| CHEMBL479382 | — | — | 1 | 7.68 |
| CHEMBL517998 | — | — | 1 | 7.57 |
| CHEMBL511292 | — | — | 1 | 7.55 |
| CHEMBL482056 | — | — | 1 | 7.54 |
| CHEMBL481173 | — | — | 1 | 7.51 |
| CHEMBL479752 | — | — | 1 | 7.47 |
| CHEMBL520942 | — | — | 1 | 7.46 |
| CHEMBL482057 | — | — | 1 | 7.30 |
| CHEMBL519128 | — | — | 1 | 7.27 |
| CHEMBL482256 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482254 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL518156 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL479958 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL479383 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL446514 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL481343 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL518155 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL481280 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL481863 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL472138 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL480131 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL480130 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL480137 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL482058 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL521259 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL481351 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL519127 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL480336 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL517533 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL470753 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL479382 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL517998 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL511292 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL482056 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL481173 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL479752 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL520942 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL482057 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL519128 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL482256 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL454760 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL520120 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL480327 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL480136 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL470929 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL481862 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL479788 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL454177 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL482255 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL520287 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL481690 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL521257 | — | IC50 | = | 3000.0 | nM | 5.52 |