Compound Detail
CHEMBL481690
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Basic Information
| ChEMBL ID | CHEMBL481690 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ODJODTWJYGPSFX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
16
Publications
0
Known Names
Molecular Properties
351.4
MW (Da)
4.61
ALogP
4
HBA
1
HBD
50.4
PSA (Ų)
0.63
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Leukotriene A-4 hydrolase CHEMBL4618 | IC50 | 6.15 | 6.15 | 710.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Leukotriene A-4 hydrolase | IC50 | = | 710.0 | nM | 6.15 | Inhibition of human recombinant leukotriene A4 hydrolase by enzyme immunoassay | 18588282 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18588282 | 10.1021/jm701575k | Unchecked | 10 |
| 18588282 | 10.1021/jm701575k | Leukotriene A-4 hydrolase | 1 |
| 18588282 | 10.1021/jm701575k | Phospholipase A2 | 1 |
| 18588282 | 10.1021/jm701575k | Prostaglandin G/H synthase 1 | 1 |
| 18588282 | 10.1021/jm701575k | Prostaglandin G/H synthase 2 | 1 |
| 18588282 | 10.1021/jm701575k | Nitric oxide synthase, inducible | 1 |
| 18588282 | 10.1021/jm701575k | Angiotensin-converting enzyme | 1 |
| 18588282 | 10.1021/jm701575k | Cathepsin B | 1 |
| 18588282 | 10.1021/jm701575k | Cathepsin G | 1 |
| 18588282 | 10.1021/jm701575k | Protease | 1 |
| 18588282 | 10.1021/jm701575k | Atrial natriuretic peptide receptor 1 | 1 |
| 18588282 | 10.1021/jm701575k | Epidermal growth factor receptor | 1 |
| 18588282 | 10.1021/jm701575k | Amine oxidase [flavin-containing] A | 1 |
| 18588282 | 10.1021/jm701575k | Amine oxidase [flavin-containing] B | 1 |
| 18588282 | 10.1021/jm701575k | Tyrosine 3-monooxygenase | 1 |
| 18588282 | 10.1021/jm701575k | Acetylcholinesterase | 1 |
Data from ChEMBL 36 via Core Engine