Assay Detail
Functional
CHEMBL990996
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Antimicrobial activity against Dictyostelium discoideum
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Dictyostelium discoideum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Determination of the microscopic equilibrium dissociation constants for risedronate and its analogues reveals two distinct roles for the nitrogen atom in nitrogen-containing bisphosphonate drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.70 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55140 | — | — | 1 | 5.05 |
| CHEMBL291736 | — | — | 1 | 4.92 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 4.89 |
| CHEMBL414849 | — | — | 1 | 4.75 |
| CHEMBL3350992 | — | — | 1 | 4.57 |
| CHEMBL1162295 | — | — | 1 | 4.52 |
| CHEMBL870 | ALENDRONIC ACID | 4.0 | 1 | 4.50 |
| CHEMBL98719 | — | — | 1 | 4.40 |
| CHEMBL56556 | — | — | 1 | - |
| CHEMBL293522 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55140 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL291736 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL414849 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3350992 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1162295 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL870 | ALENDRONIC ACID | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL98719 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL56556 | — | IC50 | < | 240000.0 | nM | - |
| CHEMBL293522 | — | IC50 | = | 310000.0 | nM | - |