Assay Detail
Binding
CHEMBL991026
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Inhibition of HCMV DNA polymerase by scintillation proximity assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human betaherpesvirus 5 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.06 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481172 | — | — | 1 | 7.12 |
| CHEMBL480773 | — | — | 1 | 6.85 |
| CHEMBL480129 | — | — | 1 | 6.77 |
| CHEMBL480325 | — | — | 1 | 6.66 |
| CHEMBL479371 | — | — | 1 | 6.66 |
| CHEMBL517841 | — | — | 1 | 6.47 |
| CHEMBL481179 | — | — | 1 | 6.38 |
| CHEMBL29711 | APHIDICOLIN | — | 1 | 6.31 |
| CHEMBL481178 | — | — | 1 | 6.29 |
| CHEMBL479772 | — | — | 1 | 6.21 |
| CHEMBL480146 | — | — | 1 | 6.16 |
| CHEMBL480772 | — | — | 1 | 6.08 |
| CHEMBL481292 | — | — | 1 | 5.99 |
| CHEMBL481111 | — | — | 1 | 5.95 |
| CHEMBL666 | FOSCARNET | 4.0 | 1 | 5.60 |
| CHEMBL479933 | — | — | 1 | 5.50 |
| CHEMBL480147 | — | — | 1 | 5.41 |
| CHEMBL479364 | — | — | 1 | 5.19 |
| CHEMBL479365 | — | — | 1 | 4.94 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481172 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL480773 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL480129 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL480325 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL479371 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL517841 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL481179 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL29711 | APHIDICOLIN | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL481178 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL479772 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL480146 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL480772 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL481292 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL481111 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL666 | FOSCARNET | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL479933 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL480147 | — | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL479364 | — | IC50 | = | 6450.0 | nM | 5.19 |
| CHEMBL479365 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 22100.0 | nM | 4.66 |