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Assay Detail

CHEMBL991220

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 7 (CHEMBL3155)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora.
Gafner S, Bergeron C, Batcha LL, Reich J, Arnason JT, Burdette JE, Pezzuto JM, Angerhofer CK.
J Nat Prod (2003) 66 : 535 -537
PubMed 12713409 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 6.40 8.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL39 SEROTONIN 3.0 1 8.59
CHEMBL487805 SCUTELLARIN 1 4.20
CHEMBL8260 BAICALEIN 2.0 1 -
CHEMBL467197 DIHYDROBAICALIN 1 -
CHEMBL512609 IKONNIKOSIDE I 1 -
CHEMBL16171 WOGONIN 1 -
CHEMBL485818 BAICALIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL39 SEROTONIN IC50 = 2.55 nM 8.59
CHEMBL487805 SCUTELLARIN IC50 = 63400.0 nM 4.20
CHEMBL8260 BAICALEIN IC50 > 350000.0 nM -
CHEMBL467197 DIHYDROBAICALIN IC50 = 179000.0 nM -
CHEMBL512609 IKONNIKOSIDE I IC50 = 135000.0 nM -
CHEMBL16171 WOGONIN IC50 > 350000.0 nM -
CHEMBL485818 BAICALIN IC50 > 200000.0 nM -