Assay Detail
Functional
CHEMBL991269
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Cytotoxicity against human HL60 cells by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of novel shikonin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.76 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480241 | — | — | 1 | 7.70 |
| CHEMBL517540 | — | — | 1 | 7.52 |
| CHEMBL480045 | — | — | 1 | 7.16 |
| CHEMBL479266 | — | — | 1 | 7.05 |
| CHEMBL520937 | — | — | 1 | 7.00 |
| CHEMBL519788 | — | — | 1 | 6.96 |
| CHEMBL481431 | — | — | 1 | 6.92 |
| CHEMBL520112 | — | — | 1 | 6.92 |
| CHEMBL481999 | — | — | 1 | 6.82 |
| CHEMBL482014 | — | — | 1 | 6.80 |
| CHEMBL481990 | — | — | 1 | 6.72 |
| CHEMBL481820 | — | — | 1 | 6.60 |
| CHEMBL481038 | — | — | 1 | 6.58 |
| CHEMBL482202 | — | — | 1 | 6.47 |
| CHEMBL480624 | — | — | 1 | 6.40 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.36 |
| CHEMBL479265 | — | — | 1 | 6.30 |
| CHEMBL480038 | — | — | 1 | 6.10 |
| CHEMBL31929 | 4'-DEMETHYLEPIPODOPHYLLOTOXIN | — | 1 | 6.09 |
| CHEMBL480820 | — | — | 1 | - |
| CHEMBL480819 | — | — | 1 | - |
| CHEMBL442888 | — | — | 1 | - |
| CHEMBL504605 | — | — | 1 | - |
| CHEMBL481989 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480241 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL517540 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL480045 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL479266 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL520937 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL519788 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL481431 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL520112 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL481999 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL482014 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL481990 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL481820 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL481038 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL482202 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL480624 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL479265 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL480038 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL31929 | 4'-DEMETHYLEPIPODOPHYLLOTOXIN | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL480820 | — | IC50 | - | — | - | |
| CHEMBL480819 | — | IC50 | - | — | - | |
| CHEMBL442888 | — | IC50 | - | — | - | |
| CHEMBL504605 | — | IC50 | - | — | - | |
| CHEMBL481989 | — | IC50 | - | — | - |