Assay Detail
Functional
CHEMBL991378
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Antiviral activity against HIV2 ROD with protease V47A mutation infected in human CEM cells assessed as inhibition of virus production after 7 days by Lenti-RT activity assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
In vitro selection and characterization of human immunodeficiency virus type 2 with decreased susceptibility to lopinavir.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.48 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.70 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 8.30 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.00 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 7.47 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 6.94 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 6.75 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 6.47 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5483011 | INDINAVIR | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL163 | RITONAVIR | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 177.0 | nM | 6.75 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 630.0 | nM | 6.20 |