Assay Detail
Binding
CHEMBL991552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CDC25B
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.94 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476648 | ADOCIAQUINONE B | — | 1 | 7.16 |
| CHEMBL489995 | — | — | 1 | 5.76 |
| CHEMBL489996 | — | — | 1 | 5.47 |
| CHEMBL491218 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476648 | ADOCIAQUINONE B | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL489995 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL489996 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL491218 | — | IC50 | = | 4130.0 | nM | 5.38 |