Assay Detail
Binding
CHEMBL991606
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Inhibition of Plasmodium falciparum plasmepsin-2
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.58 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231522 | — | — | 1 | 9.30 |
| CHEMBL452345 | — | — | 1 | 8.40 |
| CHEMBL503181 | — | — | 1 | 8.30 |
| CHEMBL452725 | — | — | 1 | 8.22 |
| CHEMBL449918 | — | — | 1 | 8.15 |
| CHEMBL448977 | — | — | 1 | 8.05 |
| CHEMBL509323 | — | — | 1 | 8.00 |
| CHEMBL448365 | — | — | 1 | 8.00 |
| CHEMBL448631 | — | — | 1 | 8.00 |
| CHEMBL508668 | — | — | 1 | 8.00 |
| CHEMBL509191 | — | — | 1 | 7.85 |
| CHEMBL499762 | — | — | 1 | 7.72 |
| CHEMBL504596 | — | — | 1 | 7.68 |
| CHEMBL444759 | — | — | 1 | 7.68 |
| CHEMBL466535 | — | — | 1 | 7.64 |
| CHEMBL509473 | — | — | 1 | 7.64 |
| CHEMBL501972 | — | — | 1 | 7.60 |
| CHEMBL500010 | — | — | 1 | 7.60 |
| CHEMBL507484 | — | — | 1 | 7.58 |
| CHEMBL499956 | — | — | 1 | 7.55 |
| CHEMBL442632 | — | — | 1 | 7.54 |
| CHEMBL502445 | — | — | 1 | 7.52 |
| CHEMBL508023 | — | — | 1 | 7.42 |
| CHEMBL510300 | — | — | 1 | 7.41 |
| CHEMBL453415 | — | — | 1 | 7.38 |
| CHEMBL507473 | — | — | 1 | 7.26 |
| CHEMBL508116 | — | — | 1 | 7.26 |
| CHEMBL502985 | — | — | 1 | 6.95 |
| CHEMBL448257 | — | — | 1 | 6.90 |
| CHEMBL506609 | — | — | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231522 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL452345 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL503181 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL452725 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL449918 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL448977 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL509323 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL448365 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL448631 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL508668 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL509191 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL499762 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL504596 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL444759 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL509473 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL466535 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL500010 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL501972 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL507484 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL499956 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL442632 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL502445 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL508023 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL510300 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL453415 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL507473 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL508116 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL502985 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL448257 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL506609 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL509164 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL506575 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL453959 | — | Ki | = | 479.0 | nM | 6.32 |
| CHEMBL503590 | — | Ki | = | 782.0 | nM | 6.11 |