Assay Detail
Binding
CHEMBL991890
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to GABAA alpha-2-beta-3-gamma-2 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; alpha-2/beta-3/gamma-2 (CHEMBL2094130) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.36 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471978 | — | — | 1 | 7.67 |
| CHEMBL58757 | — | — | 1 | 7.58 |
| CHEMBL471977 | — | — | 1 | 6.84 |
| CHEMBL45346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471978 | — | Ki | = | 21.4 | nM | 7.67 |
| CHEMBL58757 | — | Ki | = | 26.3 | nM | 7.58 |
| CHEMBL471977 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL45346 | — | Ki | > | 300.0 | nM | - |