Assay Detail
Functional
CHEMBL991976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 LAV-1 in PHA-stimulated human PBMC after 6 days
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.25 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.05 |
| CHEMBL291426 | HINOKIFLAVONE | — | 1 | 5.39 |
| CHEMBL1215433 | MORELLOFLAVONE | — | 1 | 5.16 |
| CHEMBL65320 | AGATHISFLAVONE | — | 1 | 4.47 |
| CHEMBL456859 | — | — | 1 | 4.42 |
| CHEMBL63354 | AMENTOFLAVONE | — | 1 | 4.03 |
| CHEMBL63677 | ROBUSTAFLAVONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL291426 | HINOKIFLAVONE | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1215433 | MORELLOFLAVONE | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL65320 | AGATHISFLAVONE | EC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL456859 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL63354 | AMENTOFLAVONE | EC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL63677 | ROBUSTAFLAVONE | EC50 | > | 100000.0 | nM | - |