Assay Detail
Functional
CHEMBL992476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at FXR assessed as activation by cell based luciferase transactivation assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: virtual screening, synthesis, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.38 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL519861 | — | — | 1 | 5.73 |
| CHEMBL485404 | — | — | 1 | 5.69 |
| CHEMBL520976 | — | — | 1 | 5.62 |
| CHEMBL485563 | — | — | 1 | 5.48 |
| CHEMBL483579 | — | — | 1 | 5.40 |
| CHEMBL483197 | — | — | 1 | 5.37 |
| CHEMBL519840 | — | — | 1 | 5.32 |
| CHEMBL485210 | — | — | 1 | 5.29 |
| CHEMBL520519 | — | — | 1 | 5.27 |
| CHEMBL484547 | — | — | 1 | 5.21 |
| CHEMBL483187 | — | — | 1 | 5.20 |
| CHEMBL240597 | CHENODIOL | 4.0 | 1 | 5.20 |
| CHEMBL485403 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL519861 | — | EC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL485404 | — | EC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL520976 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL485563 | — | EC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL483579 | — | EC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL483197 | — | EC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL519840 | — | EC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL485210 | — | EC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL520519 | — | EC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL484547 | — | EC50 | = | 6170.0 | nM | 5.21 |
| CHEMBL483187 | — | EC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL240597 | CHENODIOL | EC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL485403 | — | EC50 | = | 6920.0 | nM | 5.16 |