Assay Detail
Binding
CHEMBL992744
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Binding affinity to human cloned dopamine D3 receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.07 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.60 |
| CHEMBL708 | ZIPRASIDONE | 4.0 | 1 | 8.14 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.02 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.35 |
| CHEMBL476108 | — | — | 1 | 6.80 |
| CHEMBL476934 | — | — | 1 | 6.66 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.62 |
| CHEMBL140872 | — | — | 1 | 6.61 |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | 6.50 |
| CHEMBL476109 | — | — | 1 | 6.26 |
| CHEMBL476933 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL708 | ZIPRASIDONE | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL85 | RISPERIDONE | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL715 | OLANZAPINE | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL476108 | — | Ki | = | 158.8 | nM | 6.80 |
| CHEMBL476934 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL42 | CLOZAPINE | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL140872 | — | Ki | = | 244.1 | nM | 6.61 |
| CHEMBL716 | QUETIAPINE | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL476109 | — | Ki | = | 548.1 | nM | 6.26 |
| CHEMBL476933 | — | Ki | = | 600.0 | nM | 6.22 |