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Compound Detail

CHEMBL476933

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O=C(CCCN1CC2CCC(C1)N2c1ccccc1)c1ccc(F)cc1

Basic Information

ChEMBL ID CHEMBL476933
Phase Preclinical
Structure Type MOL
InChI Key OWMYGKYXZFSRMD-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

352.4
MW (Da)
4.14
ALogP
3
HBA
0
HBD
23.6
PSA (Ų)
0.73
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H25FN2O
MW 352.45
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -1.05

Activity Summary

Ki 3 meas. best 6.81

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL217
Ki 6.81 6.81 155.0 1
D(3) dopamine receptor
CHEMBL234
Ki 6.22 6.22 600.0 1
D(4) dopamine receptor
CHEMBL219
Ki 5.68 5.68 2100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18595716 10.1016/j.bmc.2008.06.030 Histamine H1 receptor 1
18595716 10.1016/j.bmc.2008.06.030 D(3) dopamine receptor 1
18595716 10.1016/j.bmc.2008.06.030 D(2) dopamine receptor 1
18595716 10.1016/j.bmc.2008.06.030 D(4) dopamine receptor 1
18595716 10.1016/j.bmc.2008.06.030 5-hydroxytryptamine receptor 1A 1
18595716 10.1016/j.bmc.2008.06.030 5-hydroxytryptamine receptor 2A 1
18595716 10.1016/j.bmc.2008.06.030 5-hydroxytryptamine receptor 2C 1

Data from ChEMBL 36 via Core Engine