Assay Detail
Binding
CHEMBL992745
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Binding affinity to human cloned dopamine D4 receptor
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.39 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.48 |
| CHEMBL150161 | — | — | 2 | 8.44 |
| CHEMBL210578 | — | — | 1 | 8.28 |
| CHEMBL140872 | — | — | 1 | 8.19 |
| CHEMBL476108 | — | — | 1 | 8.18 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.07 |
| CHEMBL476935 | — | — | 1 | 7.76 |
| CHEMBL478617 | — | — | 1 | 7.72 |
| CHEMBL708 | ZIPRASIDONE | 4.0 | 1 | 7.50 |
| CHEMBL476109 | — | — | 1 | 7.38 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.30 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.27 |
| CHEMBL340816 | — | — | 1 | 6.75 |
| CHEMBL476934 | — | — | 1 | 6.28 |
| CHEMBL476933 | — | — | 1 | 5.68 |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL150161 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL210578 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL140872 | — | Ki | = | 6.53 | nM | 8.19 |
| CHEMBL476108 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL85 | RISPERIDONE | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL476935 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL478617 | — | Ki | = | 19.2 | nM | 7.72 |
| CHEMBL708 | ZIPRASIDONE | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL476109 | — | Ki | = | 41.8 | nM | 7.38 |
| CHEMBL715 | OLANZAPINE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL42 | CLOZAPINE | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL340816 | — | Ki | = | 176.8 | nM | 6.75 |
| CHEMBL150161 | — | Ki | = | 245.5 | nM | 6.61 |
| CHEMBL476934 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL476933 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL716 | QUETIAPINE | Ki | = | 2200.0 | nM | 5.66 |