Assay Detail
Binding
CHEMBL992747
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Binding affinity to human cloned 5HT2C receptor
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.40 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL708 | ZIPRASIDONE | 4.0 | 1 | 9.14 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 8.00 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.00 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.77 |
| CHEMBL210578 | — | — | 1 | 6.06 |
| CHEMBL340816 | — | — | 1 | 5.97 |
| CHEMBL150161 | — | — | 2 | 5.90 |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | 5.85 |
| CHEMBL476108 | — | — | 1 | 5.85 |
| CHEMBL476935 | — | — | 1 | 5.45 |
| CHEMBL476109 | — | — | 1 | 5.45 |
| CHEMBL140872 | — | — | 1 | 5.38 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.33 |
| CHEMBL478617 | — | — | 1 | - |
| CHEMBL476934 | — | — | 1 | - |
| CHEMBL476933 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL708 | ZIPRASIDONE | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL85 | RISPERIDONE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL715 | OLANZAPINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL42 | CLOZAPINE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL210578 | — | Ki | = | 872.1 | nM | 6.06 |
| CHEMBL340816 | — | Ki | = | 1065.0 | nM | 5.97 |
| CHEMBL150161 | — | Ki | = | 1252.0 | nM | 5.90 |
| CHEMBL476108 | — | Ki | = | 1425.0 | nM | 5.85 |
| CHEMBL716 | QUETIAPINE | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL476935 | — | Ki | = | 3552.0 | nM | 5.45 |
| CHEMBL476109 | — | Ki | = | 3513.0 | nM | 5.45 |
| CHEMBL150161 | — | Ki | = | 3598.0 | nM | 5.44 |
| CHEMBL140872 | — | Ki | = | 4132.0 | nM | 5.38 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL478617 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL476934 | — | Ki | - | — | - | |
| CHEMBL476933 | — | Ki | - | — | - |