Assay Detail
Functional
CHEMBL993098
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cell protective activity in human MC65 cells assessed as protection against amyloid beta precursor protein C99-induced neuronal cell death after 3 days by MTT assay
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | neuronal |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Syntheses of tricyclic pyrones and pyridinones and protection of Abeta-peptide induced MC65 neuronal cell death.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.79 | 6.51 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520938 | — | — | 1 | 6.51 |
| CHEMBL473449 | — | — | 1 | 6.46 |
| CHEMBL482312 | — | — | 1 | 6.07 |
| CHEMBL521278 | — | — | 1 | 6.03 |
| CHEMBL479663 | — | — | 1 | 5.90 |
| CHEMBL520285 | — | — | 1 | 5.86 |
| CHEMBL482311 | — | — | 1 | 5.71 |
| CHEMBL480450 | — | — | 1 | 5.60 |
| CHEMBL516751 | — | — | 1 | 5.53 |
| CHEMBL482313 | — | — | 1 | 5.52 |
| CHEMBL472316 | — | — | 1 | 5.16 |
| CHEMBL482157 | — | — | 1 | 5.08 |
| CHEMBL472315 | — | — | 1 | - |
| CHEMBL513424 | — | — | 1 | - |
| CHEMBL480449 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520938 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL473449 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL482312 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL521278 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL479663 | — | EC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL520285 | — | EC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL482311 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL480450 | — | EC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL516751 | — | EC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL482313 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL472316 | — | EC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL482157 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL472315 | — | Activity | - | — | - | |
| CHEMBL513424 | — | Activity | - | — | - | |
| CHEMBL480449 | — | Activity | - | — | - |