Assay Detail
Functional
CHEMBL993365
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Antiproliferative activity against human ACHN cells after 48 hrs by sulforhodamine B assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ACHN |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.62 | 4.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460388 | — | — | 1 | 4.98 |
| CHEMBL460387 | — | — | 1 | 4.97 |
| CHEMBL483757 | — | — | 1 | 4.90 |
| CHEMBL78010 | PECTOLINARIGENIN | — | 1 | 4.82 |
| CHEMBL445978 | PECTOLINARIN | — | 1 | 4.76 |
| CHEMBL520682 | — | — | 1 | 4.27 |
| CHEMBL484937 | — | — | 1 | 4.25 |
| CHEMBL483758 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460388 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL460387 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL483757 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL78010 | PECTOLINARIGENIN | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL445978 | PECTOLINARIN | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL520682 | — | IC50 | = | 54100.0 | nM | 4.27 |
| CHEMBL484937 | — | IC50 | = | 55700.0 | nM | 4.25 |
| CHEMBL483758 | — | IC50 | = | 92600.0 | nM | 4.03 |