Assay Detail
Functional
CHEMBL993368
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Antiproliferative activity against human A375 cells after 48 hrs by sulforhodamine B assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.60 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460387 | — | — | 1 | 5.11 |
| CHEMBL78010 | PECTOLINARIGENIN | — | 1 | 5.09 |
| CHEMBL445978 | PECTOLINARIN | — | 1 | 4.48 |
| CHEMBL483757 | — | — | 1 | 4.41 |
| CHEMBL483758 | — | — | 1 | 4.28 |
| CHEMBL484937 | — | — | 1 | 4.23 |
| CHEMBL460388 | — | — | 1 | - |
| CHEMBL520682 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460387 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL78010 | PECTOLINARIGENIN | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL445978 | PECTOLINARIN | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL483757 | — | IC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL483758 | — | IC50 | = | 52300.0 | nM | 4.28 |
| CHEMBL484937 | — | IC50 | = | 58800.0 | nM | 4.23 |
| CHEMBL460388 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL520682 | — | IC50 | > | 100000.0 | nM | - |