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Assay Detail

CHEMBL993383

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(1A) dopamine receptor (CHEMBL2056)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D(1) receptor activities.
Zhang J, Chen X, Yu L, Zhen X, Zhang A.
Bioorg Med Chem (2008) 16 : 9425 -9431
PubMed 18835172 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 7.39 8.93

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL520992 1 8.93
CHEMBL520821 1 8.31
CHEMBL484538 1 8.17
CHEMBL503958 1 7.58
CHEMBL484356 1 7.41
CHEMBL485207 1 7.25
CHEMBL505308 1 6.72
CHEMBL485036 1 6.72
CHEMBL484352 1 6.46
CHEMBL485041 1 6.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL520992 Ki = 1.18 nM 8.93
CHEMBL520821 Ki = 4.88 nM 8.31
CHEMBL484538 Ki = 6.81 nM 8.17
CHEMBL503958 Ki = 26.0 nM 7.58
CHEMBL484356 Ki = 39.0 nM 7.41
CHEMBL485207 Ki = 56.0 nM 7.25
CHEMBL505308 Ki = 190.0 nM 6.72
CHEMBL485036 Ki = 190.0 nM 6.72
CHEMBL484352 Ki = 346.0 nM 6.46
CHEMBL485041 Ki = 422.0 nM 6.38