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Assay Detail

CHEMBL993399

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 in human 293T cells assessed as inhibition of viral replication after 48 hrs by multinuclear activation of galactosidase indicator assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type 293T
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Identification of minimal sequence for HIV-1 fusion inhibitors.
Nishikawa H, Oishi S, Fujita M, Watanabe K, Tokiwa R, Ohno H, Kodama E, Izumi K, Kajiwara K, Naitoh T, Matsuoka M, Otaka A, Fujii N.
Bioorg Med Chem (2008) 16 : 9184 -9187
PubMed 18819810 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 8.22 9.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL528551 1 9.41
CHEMBL525781 1 9.34
CHEMBL524843 1 9.27
CHEMBL529902 1 9.17
CHEMBL525455 1 9.06
CHEMBL499416 1 8.74
CHEMBL525435 1 8.67
CHEMBL525637 1 8.15
CHEMBL525076 ENFUVIRTIDE 4.0 1 7.82
CHEMBL524836 1 7.59
CHEMBL525569 1 7.50
CHEMBL526891 1 7.43
CHEMBL526169 1 7.34
CHEMBL524513 1 7.22
CHEMBL527068 1 6.57
CHEMBL455574 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL528551 EC50 = 0.39 nM 9.41
CHEMBL525781 EC50 = 0.46 nM 9.34
CHEMBL524843 EC50 = 0.54 nM 9.27
CHEMBL529902 EC50 = 0.68 nM 9.17
CHEMBL525455 EC50 = 0.87 nM 9.06
CHEMBL499416 EC50 = 1.8 nM 8.74
CHEMBL525435 EC50 = 2.15 nM 8.67
CHEMBL525637 EC50 = 7.1 nM 8.15
CHEMBL525076 ENFUVIRTIDE EC50 = 15.0 nM 7.82
CHEMBL524836 EC50 = 25.6 nM 7.59
CHEMBL525569 EC50 = 31.3 nM 7.50
CHEMBL526891 EC50 = 37.5 nM 7.43
CHEMBL526169 EC50 = 46.0 nM 7.34
CHEMBL524513 EC50 = 60.0 nM 7.22
CHEMBL527068 EC50 = 270.0 nM 6.57
CHEMBL455574 EC50 > 1000.0 nM -