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Assay Detail

CHEMBL993525

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of GST-tagged human LMW PTP1B IF1 isoform
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors.
Ottanà R, Maccari R, Ciurleo R, Paoli P, Jacomelli M, Manao G, Camici G, Laggner C, Langer T.
Bioorg Med Chem (2009) 17 : 1928 -1937
PubMed 19217304 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.83 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL477262 1 5.57
CHEMBL478274 1 5.51
CHEMBL514239 1 5.51
CHEMBL476666 1 5.43
CHEMBL476249 1 5.27
CHEMBL477263 1 4.79
CHEMBL478312 1 4.37
CHEMBL476669 1 4.32
CHEMBL476664 1 4.20
CHEMBL514711 1 4.15
CHEMBL514517 1 4.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL477262 IC50 = 2700.0 nM 5.57
CHEMBL478274 IC50 = 3100.0 nM 5.51
CHEMBL514239 IC50 = 3100.0 nM 5.51
CHEMBL476666 IC50 = 3700.0 nM 5.43
CHEMBL476249 IC50 = 5400.0 nM 5.27
CHEMBL477263 IC50 = 16100.0 nM 4.79
CHEMBL478312 IC50 = 43100.0 nM 4.37
CHEMBL476669 IC50 = 47700.0 nM 4.32
CHEMBL476664 IC50 = 62500.0 nM 4.20
CHEMBL514711 IC50 = 71200.0 nM 4.15
CHEMBL514517 IC50 = 87100.0 nM 4.06