Assay Detail
Binding
CHEMBL993569
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Inhibition of human lysosomal beta-glucosidase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.50 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206468 | AFEGOSTAT | 2.0 | 1 | 7.22 |
| CHEMBL110830 | DIDEOXYIMINOXYLITOL | — | 1 | 5.64 |
| CHEMBL501385 | — | — | 1 | 5.05 |
| CHEMBL1561 | MIGLITOL | 4.0 | 1 | 4.08 |
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206468 | AFEGOSTAT | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL110830 | DIDEOXYIMINOXYLITOL | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL501385 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1561 | MIGLITOL | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 240000.0 | nM | - |