Assay Detail
Binding
CHEMBL993916
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from 5HT1A receptor by vacuum filtration
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Two 5-HT 1A Receptor-Interactive Tryptamine Derivatives from the Unripe Fruit of Evodia rutaecarpa
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.42 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 7.55 |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | 2.0 | 1 | 6.39 |
| CHEMBL508030 | RHETSININE | — | 1 | 4.50 |
| CHEMBL81923 | DEHYDROEVODIAMINE | — | 1 | 4.44 |
| CHEMBL33720 | OXEDRINE | -1.0 | 1 | 4.20 |
| CHEMBL251254 | HYPEROSIDE | — | 1 | - |
| CHEMBL516621 | — | — | 1 | - |
| CHEMBL517449 | LIMONIN | — | 1 | - |
| CHEMBL85139 | RUTAECARPINE | — | 1 | - |
| CHEMBL486598 | EVODIAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7257 | MEBUFOTENIN | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL508030 | RHETSININE | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL81923 | DEHYDROEVODIAMINE | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL33720 | OXEDRINE | Ki | = | 63000.0 | nM | 4.20 |
| CHEMBL251254 | HYPEROSIDE | Ki | > | 100000.0 | nM | - |
| CHEMBL516621 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL517449 | LIMONIN | Ki | > | 100000.0 | nM | - |
| CHEMBL85139 | RUTAECARPINE | Ki | > | 100000.0 | nM | - |
| CHEMBL486598 | EVODIAMINE | Ki | > | 100000.0 | nM | - |