Assay Detail
Binding
CHEMBL993954
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Inhibition of human recombinant CDK9/cyclin T expressed in baculovirus-infected insect cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.90 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482193 | — | — | 1 | 7.37 |
| CHEMBL482211 | — | — | 1 | 6.70 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.64 |
| CHEMBL480442 | — | — | 1 | - |
| CHEMBL23327 | PURVALANOLA | — | 1 | - |
| CHEMBL521274 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482193 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL482211 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL480442 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL23327 | PURVALANOLA | IC50 | - | — | - | |
| CHEMBL521274 | — | IC50 | - | — | - |