Assay Detail
ADMET
CHEMBL993956
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Antiproliferative activity against human HEK293 cells after 48 hrs by MTS reduction assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.79 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521274 | — | — | 1 | 5.14 |
| CHEMBL482193 | — | — | 1 | 5.12 |
| CHEMBL482211 | — | — | 1 | 4.57 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 4.31 |
| CHEMBL480442 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521274 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL482193 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL482211 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 48900.0 | nM | 4.31 |
| CHEMBL480442 | — | IC50 | > | 100000.0 | nM | - |