Assay Detail
Functional
CHEMBL994176
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Cytotoxicity against human RPMI8402 cells after MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI 8402 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.68 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520825 | — | — | 1 | 9.00 |
| CHEMBL70790 | — | — | 1 | 8.70 |
| CHEMBL484348 | — | — | 1 | 8.70 |
| CHEMBL485551 | — | — | 1 | 8.52 |
| CHEMBL485632 | — | — | 1 | 8.40 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.22 |
| CHEMBL521011 | — | — | 1 | 8.10 |
| CHEMBL485382 | — | — | 1 | 7.77 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.68 |
| CHEMBL485383 | — | — | 1 | 7.19 |
| CHEMBL484370 | — | — | 1 | 6.82 |
| CHEMBL483588 | — | — | 1 | 6.60 |
| CHEMBL483589 | — | — | 1 | 6.16 |
| CHEMBL521490 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520825 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL70790 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL484348 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL485551 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL485632 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL521011 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL485382 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL485383 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL484370 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL483588 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL483589 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL521490 | — | IC50 | = | 1900.0 | nM | 5.72 |