Assay Detail
Functional
CHEMBL994177
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Cytotoxicity against camptothecin-resistant human CPT-K5 cells after MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CPT-K5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.97 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484370 | — | — | 1 | 6.85 |
| CHEMBL520825 | — | — | 1 | 6.17 |
| CHEMBL70790 | — | — | 1 | 6.05 |
| CHEMBL485632 | — | — | 1 | 6.01 |
| CHEMBL484348 | — | — | 1 | 5.89 |
| CHEMBL485551 | — | — | 1 | 5.46 |
| CHEMBL521011 | — | — | 1 | 5.35 |
| CHEMBL483588 | — | — | 1 | - |
| CHEMBL483589 | — | — | 1 | - |
| CHEMBL521490 | — | — | 1 | - |
| CHEMBL485382 | — | — | 1 | - |
| CHEMBL485383 | — | — | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484370 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL520825 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL70790 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL485632 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL484348 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL485551 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL521011 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL483588 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL483589 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL521490 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL485382 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL485383 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL65 | CAMPTOTHECIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL84 | TOPOTECAN | IC50 | > | 10000.0 | nM | - |